In Los Angeles, florist Reed Bennett (Ashton Kutcher) proposes to his girlfriend Morley (Jessica Alba) who accepts, much to the surprise of Reed’s closest friends Alphonso (George Lopez) and Julia Fitzpatrick (Jennifer Garner). Morley changes her mind and leaves Reed later in the day. Alphonso tells Reed he and Julia knew it would never work out between him and Morley, and Reed wishes they had told him. On an airplane to Los Angeles, Kate Hazeltine (Julia Roberts), a captain in the U.S. Army on a one-day leave, befriends newly single Holden Bristow (Bradley Cooper). Kate and Holden chat, play a board game, and tell jokes. When the plane lands, and Kate has to wait hours for the taxi, Holden offers his limousine, which Kate accepts, as she only has one day to spend with her family before she has to come back into the army.

Maximillian is the only survivor from a race of vampires on a Caribbean Island, and as a vampire, he must find a mate to keep the line from ending. He knows that a child had been born to a woman who had a vampire father, and he searches for her in Brooklyn. Ritas mother, who has died in an asylum, was that woman and Rita has nightmares that she does not understand. Not knowing that she is part vampire, Max woos her and attempts to bring her to her blood sucking destiny. Even though Rita has strange dreams and actions, Justice, her partner, has feelings for her and does not want her involved with this stranger Max. But it is Rita who must decide her destiny.

An unmarried 40-year-old woman turns to a turkey baster in order to become pregnant. Seven years later, she reunites with her best friend, who has been living with a secret: he replaced her preferred sperm sample with his own.

Conventional Vicky, who is engaged to Doug, travels to Barcelona to spend her summer holidays at the home of their parent's friends, Judy and Mark Nash, with her unconventional and open-minded friend, Cristina. While in a restaurant, the divorced painter Juan Antonio Gonzalo flirts and invites them to travel to Oviedo with him, and also to go to bed with him. The reluctant Vicky does not accept the invitation but Cristina agrees. Once in Oviedo, Cristina develops an ulcer so Vicky goes sightseeing alone with Juan Antonio. Vicky eventually falls in love with Juan Antonio and has sex with him. However, back in Barcelona, she does not say anything to her friend and Cristina moves into Juan Antonio's house, while Vicky marries Doug. When the unstable former wife of Juan Antonio, Maria Elena, overdoses, the painter brings her to his house and their troubled relationship harmonizes with the presence of Cristina.

Dr.R.J."Roscoe" Stevens (Martin Lawrence) is a talk show sensation who has shirked his simple Southern past and the awkward boy he used to be to dispense "you can do it" advice to millions of adoring fans. With reality TV series Survivor winner Bianca Kittles (Joy Bryant) on his arm and loads of cash in his pocket, there’s nothing he feels he hasn’t achieved.

When his parents request that he come home for their 50th wedding anniversary, RJ packs up his 10-year-old son Jamal (Damani Roberts) and his fiancee Bianca and heads back to his sleepy Southern hometown. Ready to impress his down home kin with how much he’s changed, RJ will prove he’s not the walking disaster they used to pick on. When they arrive in Georgia, he is first greeted by his cousin Reggie (who asks him for $300 worth of ice). Roscoe heads to his family's home, greeted by his parents, Roscoe Sr. and Mama Jenkins. Roscoe's cousin, Clyde, visits the family as well, and the two remain competitive as they did years before. Traveling with Clyde is Lucinda, Roscoe's love interest from his past.

Billy Tyne is a sword-fishing-boat captain out of Gloucester, highly competitive and stung by a string of poor outings. His crew is hardly back in port when he tells them he's going out again, even though it's October and the weather can turn ugly. Five join him: the young Bobby, newly in love; Murph, a devoted father recently divorced; Sully, a guy Murph despises; Bugsy, who's finally met a woman who likes him; and Alfred, a quiet Jamaican. They catch little, so they sail east, with Tyne ignoring storm warnings behind him. Finally, the fish bite, but the ice machine fails. Should they head home through the storm of the century, or wait it out and lose their catch? Fearful, the women wait.

Kirk is an average Joe who works as a TSA agent at the Pittsburgh airport with his friends. The status quo of his fairly monotonous life ends when he meets Molly, a smart, kind and gorgeous blonde. Because she's way out of his league (she's a hard 10 and he is but a 5), Kirk knows there's no way on earth she's ever going to fall for him. Or is there...?

Carl Allen is at a standstill. No future... Until the day he enrolls into a personal development program based on a very simple idea: say yes to everything! Carl discovers with amazement the magical power of "Yes", and sees his professional and romantic life turned upside down overnight: an unexpected promotion and a new girlfriend. But he'll soon discover that better can be good's enemy, and that all opportunities shouldn't be taken.

Frank Falenczyk loves his job. He just happens to be the hit-man for his Polish mob family in Buffalo, New York. But Frank's got a drinking problem and when he messes up a critical assignment that puts the family business in peril, his uncle sends him to San Francisco to clean up his act. Frank is not a touchy-feely kind of guy, but he starts going to AA meetings, gets a sponsor and a job at a mortuary where he falls for the tart-tongued Laurel, a woman who is dangerously devoid of boundaries. Meanwhile, things aren't going well in Buffalo where an upstart Irish gang is threatening the family business.

For newlyweds Carl and Molly Peterson, life can't get any sweeter as they begin anew to settle down into married life. With a nice house and established careers in tow, nothing seems to get in their way. However, Carl is about find out just how much friendship means when Dupree, his best friend has been displaced from his home and fired from his job because of attending their wedding. Taking his friend in, what Carl and Molly are about to experience is that the fine line between a few days and whatever else is after, can be a lot more than they bargained for. Especially when their friend overstays his welcome in far too many ways than he should.